产品货号：
Z18662
中文名称：
Huntingtin/HTT抗体
英文名称：
Anti-Huntingtin/HTT Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Huntingtin/HTT Antibody |
| 指标别名 | HD;HD protein;HTT;huntingtin;Huntington disease protein;IT15 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB |
| 基因名称 | HTT |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Huntington affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the near N-terminus of human Huntington disease protein. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,50% (v/v) Glycerol |
| 纯化方式 | Anti-Huntingtin was affinity purified from monospecific antiserum by immunoaffinity chromatography.This antibody is specific towards HTT.A BLAST analysis was used to suggest cross-reactivity with Human,Mouse,and Rat based on 100% sequence homology.Cross-reactivity with HTT from other sources has not been determined. |
| 浓度 | 1.1mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is six (6) months from date of opening. |
| 背景资料 | Huntingtin (also known as Huntington's disease protein,Htt and HD protein) is the protein product of a disease gene linked to Huntington's disease,a neuro-degenerative disorder characterized by loss of striatal neurons.This may be caused by an expanded,unstable trinucleotide repeat in the huntingtin gene,which translates as a polyglutamine repeat in the protein product (see partial protein sequence below).The huntingtin gene locus is large,spanning 180kb and consisting of 67 exons.It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues.The genetic defect leading to Huntington's disease may not necessarily eliminate transcription,but may confer a new property on the mRNA or alter the function of the protein.One candidate is the huntingtin-associated protein-1,highly expressed in brain,which has increased affinity for huntingtin protein with expanded polyglutamine repeats.Normal huntingtin protein shows a cytoplasmic localization.This protein is widely expressed with the highest level of expression in the brain (nerve fibers,varicosities,and nerve endings).In the brain,the regions where it can be mainly found are the cerebellar cortex,the neocortex,the striatum,and the hippocampal formation.Anti-Huntington antibodies are ideal for researchers interested in Apoptosis,Autophagy,Cytoskeleton,Neurodegeneration,Neuroscience,and Neuronal Cell Markers research. |
| Uniprot ID | P42858 |
| 推荐稀释比 | ELISA:1:20,000 - 1:60,000 IHC:1:100～1:500 IF Microscopy:1:100～1:500 WB:0.1μg/mL |
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